Histological and mechanical properties of a new-type biopsy material / 中国组织工程研究

ABSTRACT

BACKGROUND:The biopsy material induced by foreign body is autologous tissue, which, in theory, avoids the role of immune rejection and destruction faced by non-autologous implants. This biology advantage has no way to comparison by synthetic and de-cel ular materials. OBJECTIVE:To explore a biotube consisting of autologous cel s and extracel ular matrix and to evaluate its structure and mechanical features. METHODS:The biotubes were prepared by embedding silicon rods as a mold intraperitoneal y. Specimens were analyzed by mechanical tests, histological observation and superficial study. RESULTS AND CONCLUSION:It was easy to excite the biotubes prepared by embedding silicon tube intraperitoneal y. The biotube mainly included col agen-rich extracel ular matrices and myofibroblasts appearing as elongated cel s with circumferential or longitudinal orientations. At 1 month of embedding, the wal was 70-250μm in thickness and had burst strength of (1 100±187) mm Hg (1 mm Hg=0.133 kPa), with perfect sewability. The biotubes, which possess the ability for wide adjustments in their shapes, are composed of autologous cel s and extracel ular matrices, and are an ideal graft for tissue engineering because they avoid immunological rejection and have sufficient mechanical strength.