Effect of radiotherapy on loco-regional recurrence of esophageal carcinoma after surgery / 中国综合临床

ABSTRACT

Objective To investigate the effects of radiotherapy of patients with post-operative locoregional recurrence of esophageal carcinoma.Methods Retrospectively analyzed the clinical data of 60 patients with esophageal carcinoma who developed post-operative loco-regional recurrence.There were 8 patients with anastomosis relapse,21 with anastomosis and mediastinal lymph nodes metastasis,5 with abdominal lymph node metastasis,9 with supra clavicular lymph node metastasis,11 with mediastinal lymph node metastasis and 6 with mediastinal and supra-clavicular lynph node metastasis.Three-dimensional conformal radiation therapy was used to treat all the patients,with a total radiation dose of 50-70 Gy.Short-term effect,survival and adverse reactions of acute radiation were observed after radiotherapy.Results The effective rate of short term was 78.3％.The 1st,2nd and 3th year overall survival rates were 100％,50.0％,30.0％,respectively,and the middle survival phase was 15.8 months.Acute radiation side effects include16 cases of acute radiation esophagitis grade Ⅰ,Ⅱ (26.7％,16/60),4 cases of Ⅲ grade (6.7％,4/60);11 cases of acute radiation pneumonitis (18.3％,11/60);3 cases of bone marrow suppression Ⅰ,Ⅱ grade (5％,3/60) and acute cardiac injury in 1 case (1.7％,1/60).Conclusion Radiotherapy may improve the survival rate and the reduce the therapy phase of esophageal carcinoma patients with postoperative recurrence which is a good method for patients.