Expressions of N HERF1 and β-catenin in primary extramammary Paget's disease tissue and their significance / 中华皮肤科杂志
Chinese Journal of Dermatology
;
(12): 561-564, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-437755
ABSTRACT
Objective To investigate the expressions of Na+/H+ exchanger regulatory factor 1 (NHERF1) and β-catenin in extramammary Paget's disease tissue as well as their significance.Methods Immunohistochemistry was performed to detect the protein expressions of NHERF1 and β-catenin in paraffin-embeded tissue samples from 18 patients with in situ and 22 patients with invasive extramammary Paget's disease.Results There was a high expression of NHERF1 protein in 18 (81.82%) invasive and 7 (38.89%) in situ extramammary Paget's disease samples (x2 =7.78,P < 0.01).Statistical differences were observed in the membrane expression rate and cytoplasmic or nuclear expression rate of β-catenin between invasive and in situ extramammary Paget's disease tissue samples (0 (0/22) vs.33.33% (6/18),x2 =8.63,P < 0.01; 81.82% (18/22) vs.44.44% (8/18),x2 =6.08,P < 0.05).In extramammary Paget's disease in situ tissue samples,the expression of NHERF1 was negatively correlated with the cytomembrane expression of β-catenin (ρ =-0.488,P < 0.01),but positively correlated with the cytoplasmic or nuclear expression of β-catenin (ρ =0.623,P < 0.01),and there was a negative correlation between the cytomembrane and cytoplasmic or nuclear expression of β-catenin (ρ =-0.572,P < 0.01).Conclusions There is an abnormal expression of NHERF1 and β-catenin in extramammary Paget's disease tissue,which may be associated with the initiation,progression,and invasion of primary extramammary Paget's disease.
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Dermatology
Year:
2013
Type:
Article
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