Prevalence and risk factors of anemia in adult patients with antineutrophil cytoplasmic antibody associated vasculitis / 中国医师进修杂志

ABSTRACT

Objective To study prevalence and risk factors of anemia in adult patients with antineutrophil cytoplasmic antibody (ANCA) associated vasculitis.Methods The clinical data of 72 adult patients with ANCA associated vasculitis were studied retrospectively.According the age,the patients were divided into youth group (age ＜ 65 years,43 cases) and old group (age ≥ 65 years,29 cases).Baseline characteristics and lab measurements were recorded and analyzed.Risk factors of anemia were evaluated using Logistic analysis.Results In 72 adult patients with ANCA associated vasculitis,47 cases (65.3％)developed anemia.The prevalence of anemia in the youth group was 55.8％ (24/43),and that in the old group was 79.3％ (23/29).The prevalence of anemia in the old group was significantly higher than that in the youth group (P ＜ 0.01).When adjusted for confounders,age (increased 10 age,OR =1.23,95％ CI 1.12-1.95,P=0.001),diabetes (OR =1.34,95％ CI 1.14-1.89,P=0.013) and massive proteinuria (OR =1.11,95％ CI 1.05-1.76,P =0.011) were independently associated with increased risk of anemia in all patients.Conclusions The prevalence of anemia in the older patients is higher than that in the younger patients with ANCA associated vasculitis.Age(increased 10 age),diabetes and massive proteinuria are independently risk factor of anemia in adult patients with ANCA associated vasculitis.