The analysis and expression of human epidermal growth factor-2,ventricular endothelial growth factor,glucose transporter-1 in breast cancer with lymph metastasis / 中国医师进修杂志

ABSTRACT

Objective To analyze the expression of human epidermal growth factor (HER)-2,ventricular endothelial growth factor (VEGF),glucose transporter (GLUT)-1 in breast cancer with lymph metastasis.Methods Eighty cases with breast cancer were selected,and 46 cases without lymph metastasis (non-lymph metastasis group),34 cases with lymph metastasis (lymph metastasis group).Immunohistochemical staining SP was used to detect the expression of HER-2,VEGF,GLUT-1.The level of HER-2,VEGF,GLUT-1 in different grade was analyzed.Results The positive expression of HER-2,VEGF,GLUT -1 was 13.0％(6/46),45.7％(21/46),17.4％(8/46) in non-lymph metastasis group,and 88.2％(30/34),88.2％ (30/34),88.2％ (30/34) in lymph metastasis group.There was significant difference between two groups(P ＜ 0.01 or ＜ 0.05).There was significant difference in the expression of HER-2,VEGF,GLUT-1 in grade Ⅰ,Ⅱ,Ⅲ between two groups (P＜0.01).Conclusion HER-2,GLUT-1 and VEGF in breast cancer with lymph metastasis for high expression,different tumor classification expresses different.