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Pharmacokinetic study of potential drug shionone / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy ; (12): 2268-2270, 2013.
Article in Chinese | WPRIM | ID: wpr-438131
ABSTRACT
Objective To develop a simple,sensitive,and accurate method for the determination of shionone in rat plasma after administration of shionone.Methods The separation was developed by HPLC on a Waters shieldTM RP18 column (150mm × 3.9mm,5 μm) with a mobile phase composed of acetonitrile-0.05% phosphoric acid water (982) at a flow rate of 1.0 mL/min.UV Detector was set at 200nm.Results The linear range of the standard curves was 0.043-1.720 μg/ml with the correlation coefficient of 0.995.The intra-and inter-day precisions were all below 10%.Conclusion The developed method can be successfully applied to the pharmacokinetic study.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Primary Medicine and Pharmacy Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Primary Medicine and Pharmacy Year: 2013 Type: Article