Effects and safety of intra-articular injection of recombinant human tumor necrosis factor-α receptor Ⅱ :IgG Fc fusion protein in patients with refractory knee effusion / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy
;
(12): 2313-2314, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-438149
ABSTRACT
Objective To evaluate the clinical efficacy and safety of the intra-articular injection of recombinant human tumor necrosis factor-α receptor ⅡIgG Fc fusion protein (rhTNFRFc) in inflammatory arthritis patients with refractory knee effusion.Methods Ten inflammatory arthritis patients presented with refractory knee effusion after treatment of intra-articular steroid injection were involved.They received intra-articular injection rhTNFRFc (12.5mg twice weekly).The clinical efficacy and safety were assessed the first and second week after injection.Results At 1 week and 2 weeks,the total effective rate was 60% and 70% respectively.Patients and physicians global assessment score (visual analogue scale VAS 0-100mm),joint tenderness and movement pain scale (VAS) were significantly improved.Knee circumference was reduced as compared with baseline (all P < 0.05).Conclusion Intra-artiular injection of rhTNFRFc in improving patients with refractory knee effusion is a worthwhile clinical treatment attempt.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Primary Medicine and Pharmacy
Year:
2013
Type:
Article
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