Possible Roles of UL112-113 Proteins in Human Cytomegalovirus DNA Replication
Journal of Bacteriology and Virology
;
: 162-168, 2012.
Article
in Korean
| WPRIM
| ID: wpr-43862
ABSTRACT
DNA replication of human cytomegalovirus (HCMV) is a highly regulated process that requires specific interactions between cis-acting lytic origin of replication (oriLyt) and trans-acting viral proteins. Formation of the replication initiation complex is also regulated by specific interactions among viral replication proteins. HCMV replication proteins include origin-binding proteins, core proteins that work in replication forks, and regulatory proteins that modulate host cell functions. This letter describes intriguing questions regarding how HCMV origin-binding proteins interact with oriLyt to initiate DNA replication and how the regulatory UL112-113 proteins, which are found only in beta-herpesviruses, function to promote viral DNA replication.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Viral Proteins
/
DNA
/
DNA, Viral
/
Proteins
/
Replication Origin
/
Cytomegalovirus
/
DNA Replication
Limits:
Humans
Language:
Korean
Journal:
Journal of Bacteriology and Virology
Year:
2012
Type:
Article
Similar
MEDLINE
...
LILACS
LIS