Research progress of molecular targets and cell signaling of nanoparticles / 国际生物医学工程杂志

ABSTRACT

New progress in the area of nanoparticle research are the studies on interactions between nanoparticles (NPs) and biological molecules in body fluid,cellular microenvironment,intracellular components or secreted cellular proteins such as cytokines,growth factors and enzymes and the use of engineered NPs to target various signal transduction pathways in cancer therapy.NPs-induced toxicological mechanism has become one of the most studied topics.Oxidative stress result is not sufficient to explain all the biological effects.This article reviews the latest research progress in nanotoxicology from the perspective of cellular mechanisms,including the interactions between NPs and the cell membrane receptor,cell oxidative stress result,cell apoptosis induction and the effects of NPs on cell cycle.