Relationship of serum insulin-like growth factor-Ⅰ level with cardiovascular risk factors in male subjects / 中华内分泌代谢杂志

ABSTRACT

The level of serum insulin-like growth factor-Ⅰ (IGF-Ⅰ) in 308 healthy men aged 20 to 79 years was measured by ELISA.and fasting blood glucose (FBG),two hours postprandial blood glucose (2hPG),fasting insulin (FINS),high density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C) and C reactive protein (CRP) were determined at the same time.The results showed that the average level of serum IGF-Ⅰ was 140.61 ±39.04 ng/ml.Compared with the group aged 20 ～ 29 years,the levels of IGF-Ⅰ in other age groups were all loweded (P＜0.05).After adjusting for age,partial correlate analysis showed that the level of serum IGF-Ⅰ was negatively correlated with triglyceride (TG),LDL-C,systolic blood pressure,2hPG,CRP (P＜0.05 or P＜0.01),and positively correlated with HDL-C (P＜0.01) . Based on the quartile levels of IGF-Ⅰ,systolic blood pressure and TG were decreased and HDL-C was increased with increased IGF-Ⅰ levels(P＜0.01).