CD5-negative Blastoid Variant Mantle Cell Lymphoma with Complex CCND1/IGH and MYC Aberrations
Annals of Laboratory Medicine
;
: 95-98, 2012.
Article
in English
| WPRIM
| ID: wpr-43978
ABSTRACT
The coexistence of CCND1/IGH and MYC rearrangements in mantle cell lymphoma (MCL) is a rare finding associated with a very poor prognosis. In this study, a patient with blastoid variant (MCL) is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient only survived for 1 month following diagnosis. Conventional cytogenetic study, FISH, and multicolor FISH (mFISH) demonstrated the involvement of the BCL1/CCND1 locus in a complex translocation, t(3;11)(q25;p15)t(11;14)(q13;q32). In addition, subclonal abnormalities in the 8q24 region, manifested as a t(8;14)(q24;q32)/MYC rearrangement, were identified. To the best of our knowledge, this is the first MCL case in Korea bearing these complex genomic aberrations.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Translocation, Genetic
/
Bone Marrow
/
Chromosomes, Human, Pair 3
/
Chromosomes, Human, Pair 11
/
Chromosomes, Human, Pair 14
/
Gene Rearrangement
/
Oncogene Proteins, Fusion
/
Immunophenotyping
/
Proto-Oncogene Proteins c-myc
/
In Situ Hybridization, Fluorescence
Type of study:
Prognostic study
Limits:
Aged
/
Aged80
/
Humans
/
Male
Language:
English
Journal:
Annals of Laboratory Medicine
Year:
2012
Type:
Article
Similar
MEDLINE
...
LILACS
LIS