Pre- and Post-transfusion Testing for Hepatitis B Virus Surface Antigen and Antibody in Blood Recipients: A Single-Institution Experience in an Area of High Endemicity
Annals of Laboratory Medicine
;
: 73-78, 2012.
Article
in English
| WPRIM
| ID: wpr-43983
ABSTRACT
BACKGROUND:
Hepatitis B remains the most common transfusion-transmitted viral infection. We explored the current status of pre-transfusion screening and post-transfusion follow-up testing for hepatitis B virus (HBV) surface antigen (HBsAg) and antibodies (anti-HBs) in blood recipients from an area of high HBV endemicity.METHODS:
A total of 7,780 blood recipients were transfused with at least 1 unit of blood component at a single university hospital in Korea between January 2006 and December 2009. Their medical records were reviewed, and their demographic and transfusion-related data were analyzed.RESULTS:
Pre-transfusion HBsAg and anti-HBs levels were tested in 77.6% (6,037/7,780) of the recipients. The results varied widely according to recipient age. In all, 32.8% (1,982/6,037) of the recipients who were tested had dual negative pre-transfusion results for HBsAg and anti-HBs and, therefore, were at increased risk of HBV transmission. Post-transfusion follow-up testing for HBsAg and/or anti-HBs was performed in 22% (436/1,982) of the increased-risk group.CONCLUSIONS:
Our data show that current transfusion-related laboratory testing practice is not sufficient to properly investigate possible post-transfusion infections. Routine laboratory tests, including HBsAg and anti-HBs, should be recommended in transfusion guidelines.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood Transfusion
/
Demography
/
Risk
/
Retrospective Studies
/
Cohort Studies
/
Endemic Diseases
/
Hepatitis B
/
Hepatitis B Antibodies
/
Hepatitis B Surface Antigens
Type of study:
Etiology study
/
Practice guideline
/
Incidence study
/
Observational study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
English
Journal:
Annals of Laboratory Medicine
Year:
2012
Type:
Article
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