The Effect of Isoflurane Anesthesia on the Succinylcholine - Induced Muscle Fasciculations in Children / 대한마취과학회지

ABSTRACT

Forty children were anesthetized with either thiopental 5mg/kg followed by succinylcholine 1.5mg/kg I.V. or with isoflurane 3.5 vol% in 66% nitrous oxide in oxygen via a face mask followed by succinylcholine 1.5mg/kg I.V.. The study was randomized, in the thiopental group, fasciculation were seen in all children and in the isoflurane group, in 10 of 20 children(p<0.001). The intensity of the fasciculation was 1.6+/-0.7 in the thiopental group and 0.6+/-0.4 in the isoflurane group(p<0.001). The duration of fasciculstion was 35.6+/-13.6sec in the thiopental group and 9.0+/-8.0 sec in the isoflurane group(p<0.001). No cardiac arrhythmias were noted in either group, but heart rates were inereased significantly after intubation in both group(p<0.001). ln conclusion, isoflurane in nitrous oxide may inhibit succinylcholine-induced muscle fasciculation in children.