Efficacy and Safety of Solifenacin in Neurogenic Detrusor Overactivity / 中国康复理论与实践

ABSTRACT

Objective To assess the efficacy and safety of solifenacin in patients with neurogenic detrusor overactivity (NDO). Methods 50 patients with NDO received solifenacin 5 mg/d. During the treatment period, the voiding diary, Patient Perception of Bladder Condi-tion-Scale (PPBC-S) and side effects were recorded. Results 2 weeks and 12 weeks later, the volume of the catheterization every time in-creased from (224.2 ± 15.7) ml at baseline to (302.6 ± 23.3) ml and (301.3 ± 21.1) ml (P<0.05);the volume of leakage every day decreased from (753.9±121.7) ml to (444.1±87.1) ml and (449.1±89.2) ml (P<0.05);PPBC-S score decreased from (5.12±0.072) to (4.36±0.073) and (4.36±0.068) (P<0.05). There were 3 cases (6%) with dry mouth, and no patients complained dry eyes and blurred vision. Conclusion Solif-enacin is safe and effective, and can significantly improve the quality of life in patients with NDO.