Research Progress of Cyclin D1,P16 and CDK4 in Gastric Cancer / 昆明医科大学学报

ABSTRACT

Gastric cancer is a malignant tumor with the second highest incidence and mortality in the world, and China is one of the countries with the highest incidence of gastric cancer in the world. Research on the regulation of cell cycle protein can provide effective evidence for the mechanism of tumor and gene therapy.G1/S phase is the key point for cell cycle regulation,Cyclin D1 and CDK4 gene and P16 play important roles in this phase and have great correlation with gastric cancer,but the exact relationship between these genes and gastric cancer is still unclear. In order to better understand the expression of Cyclin D1 and CDK4 gene and P16 in gastric cancer, the related researches in recent years were summarized in this paper.