ERS response mediates glucolipotoxicity-induced β-cell apoptosis / 基础医学与临床
Basic & Clinical Medicine
;
(12): 1337-1340, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-440624
ABSTRACT
As one of the most sensitive cells of endoplasmic retieulum stress (ERS), pancreatic β-cells have an a-bundance of endoplasmic reticulum. Fatty acids cause apoptosis of β-cells and might contribute to β-cell loss in type 2 diabetes mellitus via the induction of ERS. Glucose is an amplifier of the ERS response to fatty acid, leading to increased β-cell apoptosis. ERS response mediates glucolipotoxicity-induced β-cell apoptosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Basic & Clinical Medicine
Year:
2009
Type:
Article
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