Research progresses on K-RAS mutation of non-small cell lung cancer / 基础医学与临床
Basic & Clinical Medicine
;
(12): 212-214, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-440633
ABSTRACT
Mutated K-RAS is found in 15%~30% NSCLC patients, the mutations of K-RAS and EGFR are mutually exclusive,K-RAS mutations have poor sensitivity to EGFR-TKIs. The response of C-225 is not restricted to mutated K-RAS, NSCLC patients with K-RAS mutations are associated with unfavorable prognosis. A number of different approaches such as Ftase inhibitors, RAF inhibitors, MEK inhibitors aimed at abrogating K-RAS activity to improve clinical response have been explored in clinical trials.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Basic & Clinical Medicine
Year:
2010
Type:
Article
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