Compound Betamethasone enhances the expression of olfactory marker protein in olfactory mucosa of mice injured by influenza virus / 基础医学与临床

ABSTRACT

Objective To investigate the effects of compound Betamethasone on the expression of olfactory marker protein(OMP)in murine olfactory mucosa injured by influenza virus.Methods An animal model was developed by intranasal application of influenza virus to mice.Compound Betamethasone was injected i.p.(3.5 mg/kg)on day 2 and day 4 after the insult.The expression of OMP was tested by immunohistochemistry and Western blot.Results The expression of OMP was significantly downregnlated in the olfactory mucosa of influenza virus control group 1 and influenza virus control group 2;the expression of OMP was significantly upregulated in the olfactory mucosa of post-infection compound Betamethasone group 1 and post-infection compound Betamethasone group 2.Conclusion Compound Betamethasone can enhance the expression of OMP in the olfactory mucosa injured by influenza virus.