Associations of alcohol consumption and alcohol flush reaction with leukocyte telomere length in Korean adults
Nutrition Research and Practice
;
: 334-339, 2017.
Article
in English
| WPRIM
| ID: wpr-44069
ABSTRACT
BACKGROUND/OBJECTIVES:
Telomere length is a useful biomarker for determining general aging status. Some studies have reported an association between alcohol consumption and telomere length in a general population; however, it is unclear whether the alcohol flush reaction, which is an alcohol-related trait predominantly due to acetaldehyde dehydrogenase deficiency, is associated with telomere length. This cross-sectional study aimed to evaluate the associations of alcohol consumption and alcohol flush reaction with leukocyte telomere length (LTL). SUBJECTS/METHODS:
The study included 1,803 Korean adults. Participants provided blood specimens for LTL measurement assay and reported their alcohol drinking status and the presence of an alcohol flush reaction via a questionnaire-based interview. Relative LTL was determined by using a quantitative polymerase chain reaction. Statistical analysis used multiple linear regression models stratified by sex and age groups, and potential confounding factors were considered.RESULTS:
Age-specific analyses showed that heavy alcohol consumption (> 30 g/day) was strongly associated with a reduced LTL in participants aged ≥ 65 years (P 15 g/day of alcohol (P < 0.01). No significant alcohol consumption or alcohol flush reaction associations with LTL were observed in the sex-specific analyses.CONCLUSIONS:
The results suggest that older alcohol drinkers, particularly those with the alcohol flush reaction, may have an accelerated aging process.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxidoreductases
/
Aging
/
Alcohol Drinking
/
Linear Models
/
Polymerase Chain Reaction
/
Cross-Sectional Studies
/
Telomere
/
Aldehyde Dehydrogenase
/
Leukocytes
/
Acetaldehyde
Type of study:
Observational study
/
Prevalence study
/
Risk factors
Limits:
Adult
/
Humans
Language:
English
Journal:
Nutrition Research and Practice
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS