Shape-memory intratubal contraceptive material versus other intratubal contraceptive materials:Characteristics analysis / 中国组织工程研究

ABSTRACT

BACKGROUND:Intratubal contraceptive devices are simple and effective, which can cause less interference on female reproductive function and endocrine balance. OBJECTIVE:To explain the advantages and adverse effects of shape-memory intratubal contraceptive material and other intratubal contraceptive materials. METHODS:A computer-based search of Wanfang, CNKI and PubMed was performed to search related articles concerning shape-memory intratubal contraceptive material and other intratubal contraceptive materials published from 1996 to 2013. RESULTS AND CONCLUSION:The main intratubal contraceptive materials include memory metal biomaterials, non-degradable polymer biomaterials, and degradable polymer biomaterials. After implantation, the memory-shape intratubal contraceptive device plays a stimulating role in the tubal epithelium for a short time, but the effect on the mucosal epithelial layer of the fal opian tube is transient. With the increasing time of implantation, inflammatory reactions of the tubal epithelium relieve gradual y with repair of vil i on the tubal wal , indicating there is a reproductive tissue basis of fal opian tube recanalization. Polyethylene materials are characterized as high impact resistance, abrasion resistance, excellent stability to chemical drugs, water absorption, electric insulation, and bioinert, which are used as stent materials of almost al the intrauterine devices. Silicone is characterized as heat resistance, cold resistance, non-toxicity, resistance to biological aging, chemical stability, physical inertia, physical and mechanical properties, and silicone, after implantation into human body, cannot cause foreign body reaction. Polylactic acid has good chemical inertness, biocompatibility and ease of processing, and may be stil present in the body after 5 years of implantation.