Hypoxia-inducible factor-1 and transforming growth factor-β in tumor / 国际肿瘤学杂志

ABSTRACT

Hypoxia-inducible factor-1 (HIF-1) is one of the most important hypoxia signal transmission factor,and it has been observed in many human tumors.HIF-1 could play a role of promoting tumor by regulating the expression level of transforming growth factor-β in vivo and in vitro,and then affecting the development and prognosis of tumor.