Progress in Phospholipase A2 and Its Relevant Chinese Materia Medica / 世界科学技术-中医药现代化

ABSTRACT

Phospholipase A2 (PLA2) is the speed limit enzyme that liberates the sn-2 fatty acyl chains from phospho-lipids to yield nonesterified fatty acids and lysophospholipids. Its metabolites have a wide range of biological activity in a series of physiological and pathological process such as gene expression, energy metabolism, plasmalemma re-configuration, signal transduction, inflammation, trauma, and etc. This review introduced members of the PLA2 super-family and their functions. And the effect on the activity and/or mass of PLA2 family was summarized with a purpose to promote related research, of which more than 100 items included prescriptions, herbs and their active ingredients in 150 articles were collected from the database.