Effects of Salvianolate Injection on the Levels of Serum L-1βand IL-18 in Acute Exacerbated Chronic Obstructive Pulmonary Disease Patients / 浙江中医药大学学报

ABSTRACT

[Objective] To investigate the effect of salvianolate injection on the levels of Serum interleukin-1β(IL-1β)and interleukin-18(IL-18) in acute exacerbated chronic obstructive pulmonary disease(AECOPD) patients. [Methods] Fifty-eight patients with acute exacerbated COPD from Respiratory Dep. of thrid Hospital Affiliated to Zhejiang Chinese Medical University, were randomly assigned to the treatment group(28 cases) and the control group(30 cases). Routine therapies for COPD were given to patients in the control group, while 20mg salvianolate injection was given to those in the treatment group by intravenous dripping, once daily for total 10 days. The levels of IL-18, IL-1β and blood gas analysis were evaluated before and 10 days after therapy. The levels of the cytokins were compared with 30 normal controls. [Result] There were no significant differences in the value of IL-1β,IL-18,arterial partial pressure of carbon dioxide(PaCO2),arterial partial pressure of oxygen(PaO2) before treatment between two groups. Compared with the blank control group, the levels of serum IL-1β,IL-18 in patient with AECOPD were increased significantly( P<0.01). When compared with before treatment and with the control group, the levels of IL-1β,IL-18,PaCO2 decreased more significantly in the treatment group after treatment.The PaO2 in treatment group was higher than in control group. There were significant differences between two groups.[Conclusions] Salvianolate injection can reduce the secretion IL-1β, IL-18 in patient with AECOPD, which maybe through certain anti-inflammatory effects to improve clinical efficacy of COPD pa-tients.