The effects of heart rate variability of trimetazidine for elderly patients with chronic heart failure / 重庆医学

ABSTRACT

Objective To investigate the effects of heart rate variability of trimetazidine for elderly patients with chronic heart failure .Methods 290 cases senile patients with chronic heart failure were randomly divided into observation group and the control group(n=145 ,each group) .two groups of patients were taking standardization of chronic heart failure treatment ,observation group added with trimetazidine 20 mg/time ,3 times/d ,for 12 weeks .Observed two groups of patients before and after treatment between normal R-R standard deviation(SDNN) ,R-R phase difference between five minutes root mean square (rMSSD) ,5 minutes period av-erage standard deviation between normal R-R(SDANN) ,R-R> 50 ms phase difference between heart rate proportion (pNN50) , heart rate ,left ventricular ejection index(LVEF) ,left ventricular end-diastolic diameter(LVEDd) ,Patients with 6 min walk test(6-MWDS) changes .Results The heart rate ,6-MWDS ,LVEF and LVEDd in both groups has no statistical significance before treat-ment(P>0 .05) .Compared with before treatment ,6-MWDS ,LVEF increased after the treatment (P0 .05) ,after treatment the above indicators were higher than before treatment (P< 0 .05) ,after treatment SDNN , rMSSD ,SDANN ,pNN50 in observation group increased more significantly than the control group(P<0 .05) .Conclusion On the basis of conventional anti heart failure therapy combined with trimetazidine treatment of elderly patients with chronic heart failure can obviously increase the heart rate variability ,and improve the autonomic nerve function and cardiac function .