Correlation of B-type natriuretic peptide levels and echocardiographic parameters in preterm infants with patent ductus arteriosus / 소아과
Korean Journal of Pediatrics
;
: 183-189, 2016.
Article
in English
| WPRIM
| ID: wpr-44138
ABSTRACT
PURPOSE:
This study aimed to evaluate the correlation, according to postnatal age, between plasma B-type natriuretic peptide (BNP) levels and echocardiographic parameters for the assessment of patent ductus arteriosus (PDA) in preterm infants with respiratory distress.METHODS:
We enrolled 42 preterm infants with respiratory distress who underwent serial echocardiographic evaluation with simultaneous plasma BNP measurements until ductal closure. The correlations between BNP levels and the following 4 representative echocardiographic parameters were studied diameter of the ductus arteriosus (DA), ratio of the left atrial diameter to the aortic diameter (LA/Ao), ratio of the PDA diameter to the infant's left pulmonary artery diameter (PDA/LPA), and the antegrade diastolic flow of LPA (DFLPA).RESULTS:
BNP levels were significantly correlated to the magnitude of the ductal shunt, comprising the DA diameter, PDA/LPA ratio, LA/Ao ratio, and antegrade DFLPA for the overall study period. The earliest significant correlation, starting from postnatal day 2, was observed between the LA/Ao ratio and BNP levels. The PDA/LPA ratio and the antegrade DFLPA showed significant correlations with BNP levels postnatal day 3 onward, and with the DA diameter, postnatal day 5 onward.CONCLUSION:
BNP levels and echocardiographic parameters showed a positive correlation, but the significance of the correlations differed according to the postnatal age, especially during the first few days of life.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Pulmonary Artery
/
Infant, Premature
/
Echocardiography
/
Natriuretic Peptide, Brain
/
Ductus Arteriosus
/
Ductus Arteriosus, Patent
Limits:
Humans
/
Infant, Newborn
Language:
English
Journal:
Korean Journal of Pediatrics
Year:
2016
Type:
Article
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