Cytomegalovirus Infection and Memory T Cell Inflation
Immune Network
;
: 186-190, 2015.
Article
in English
| WPRIM
| ID: wpr-44176
ABSTRACT
Cytomegalovirus (CMV) infection in healthy individuals is usually asymptomatic and results in latent infection. CMV reactivation occasionally occurs in healthy individuals according to their immune status over time. T cell responses to CMV are restricted to a limited number of immunodominant epitopes, as compared to responses to other chronic or persistent viruses. This response results in progressive, prolonged expansion of CMV-specific CD8+ T cells, termed 'memory inflation'. The expanded CMV-specific CD8+ T cell population is extraordinarily large and is more prominent in the elderly. CMV-specific CD8+ T cells possess rather similar phenotypic and functional features to those of replicative senescent T cells. In this review, we discuss the general features of CMV-specific inflationary memory T cells and the factors involved in memory inflation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
T-Lymphocytes
/
Immunodominant Epitopes
/
Cytomegalovirus Infections
/
Cytomegalovirus
/
Inflation, Economic
/
Memory
Limits:
Aged
/
Humans
Language:
English
Journal:
Immune Network
Year:
2015
Type:
Article
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