Monitoring and analysis of drug resistance of bacteria in 5042 blood samples / 中国综合临床

ABSTRACT

Objective To investigate the drug resistance of patients samples in terms of pathogenic bacteria in order to provide the basis for clinical diagnosis,treatment of blood infection.Methods Six hundred and seventy-one bacteria strains out of 5042 blood samples of hospitalized patients were used to analyze its characters and drug resistance from January 2009 to December 2012 in the people's hospital of inner mongolia autonomous region.BacT AIERT 3D automatic rapid microbial detection system was applied to perform blood culture.The bacteria identification and drug sensitivity test (MIC method) were detected by using VITEK 2Compact automatic bacteria identification instrument.Results Bacteria positive rate was 13.3％ (671/5042),of which the gram negative bacilli accounted for 49.9％ (335/671),and gram positive for 40.8％ (274/671).The top 5 bacteria strains of blood samples were escherichia coli,staphylococcus,staphylococcus aureus,klebsiella pneumoniae and staphylococcus aureus.The pathogenic bacteria rates of blood samples were 30.5％(29/95),44.4％ (55/124) and 52.5％ (94/179) respectively during 2009-2012.The main source of blood bacteria renal were department of internal medicine ward (12.1％,81/671),department of general surgery (11.6％,78/671),and ICU ward (10.6％,71/671).The detected bacteria rate in department of general surgery separation rate increased to the first in 2012 from fifth in 2009.However the detected bacteria rate in department of internal medicine was down to the tenth in 2012 from the third in 2009.The drug resistance rate of imipenem,piperacillin/tazobactam,cefotaxime,ceftazidime resistant cefotetan on escherichia coli and klebsiella pneumoniae were all less than 9.7％,and the rate of linezolid,vancomycin,teicoplanin,quinupristin/dafoe leptin and nitrofurantoin resistance of staphylococcus aureus,staphylococcus bacteria and gold staphylococcus aureus were all less than 2.3％.Conclusion The distribution,sources and drug resistance of pathogenic bacteria had been changed recently.Therefore the laboratory shall strengthen the monitoring of drug resistance of bacteria in the bloodstream infection in order to guide clinical rational application of antibiotics.