A compared study on Gd+-EOB-DTPA and Gd+-DTPA-enhanced MRI in detection of hepatocellular carcinoma / 中华普通外科杂志

ABSTRACT

Objective To evaluate the difference of image quality and lesion detection between Gd+-EOB-DTPA with Gd+-DTPA-enhanced MRI in cases of hepatocellular carcinoma (HCC).Methods A total of 21 HCC patients underwent both Gd+-EOB-DTPA and Gd+-DTPA-enhanced MRI examination,comparing the difference between the two agents using the value of lesion display quality index,sensitivity,specificity,positive and negative predictive value,diagnosis accuracy and CNR.Results There were 25 lesions on the 21 HCC patients with 9 lesions ＜ 1.0 cm.24 lesions showed hypointensity and 1 lesion showed isointensity on hepatobiliary phase with Gd+-EOB-DTPA-enhanced MRI.15 lesions showed hypointensity,5 lesions showed isointensity and 5 lesions showed hyperintensity on portal venous phase with Gd+-DTPA-enhanced MRI.The value of lesion (in particular for the lesion ＜ 1.0 cm)display quality index,sensitivity,specificity,positive and negative predictive value,diagnosis accuracy on Gd+-EOB-DTPA-enhanced MRI and Gd+-DTPA-enhanced MRI were 17scors,89％,89％,89％,89％ and 12 scors,33％,33％,33％,67％ respectively.CNR on hepatobiliary phase with Gd+-EOB-DTPA-enhanced MRI was 639.35.CNR on arterial phase and portal venous phase with Gd+-DTPA-enhanced MRI were 225.25 and 93.25 respectively.The data showed that Gd+-EOB-DTPA-enhanced MRI was better than that of Gd+-DTPA-enhanced MRI.Conclusions Gd+-EOB-DTPA-enhanced MRI displays lesions (especially for lesions ＜ 1.0 cm) better compared with Gd+-DTPA-enhanced MRI increasing the diagnostic accuracy of small HCC.