The mechanism of nebulized drugs in the treatment of patients with exacerbation of bronchiolitis / 国际儿科学杂志

ABSTRACT

Bronchiolitis is the most common acute infection of the lower respiratory tract in infancy,characterized by rhinorrhea,cough,Wheezing,respiratory distress and hypoxemia,and is most often caused by the respiratory syncytial virus (RSV).Some patients may develop into asthma,which is serious threat to the health of infants and young children.It is one of the focal points of pediatric clinical research.For the treatment of bronchiolitis,there is still no specially good effects of the treatment,the goal is to remove the obstruction of respiratory tract,improve ventilation and control the wheezing,prevent complicated by heart failure and respiratory failure.Medication mainly includes antiviral medication,and asthma and immunotherapy.The inhalation therapy is to put the drugs as a particulate directly into target tissue,acting on the trachea with drug receptors to play curative efficacy,which has rapid absorption.Thus nebulized medication therapy has been more and more recognized clinically.There are a wide variety of nebulized drugs.Commonly used in the literature are β2 agonists,epinephrine,corticosteroids,magnesium sulfate,ambroxol,ribavirin and hypertonic saline,etc.The Mechanism of various nebulized inhalation drug commonly used in the treatment of bronchiolitis recent years are reviewed.