Intrathecal lamotrigine blocks and reverses antinociceptive morphine tolerance in rats / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 687-692, 2009.
Article
in English
| WPRIM
| ID: wpr-44233
ABSTRACT
BACKGROUND:
Chronic administration of morphine leads to the development of tolerance. We investigated the effects of intrathecal lamotrigine on the spinal morphine tolerance in rats that are undergoing tail flick tests.METHODS:
Sprague-Dawley rats were given intrathecal injections of saline 10 microl, lamotrigine 300 microg, morphine 15 microg or lamotrigine plus morphine combinations for 7 days (lamotrigine was given for days 1-7, days 1-3 or days 5-7). The acute and chronic nociceptive sensitivities were assessed using a tail flick test in which the distal 5 cm of the tail was dipped into warm water before and 30 minutes after the drug injection. With successive injections of morphine on day 8, a cumulative antinociceptive dose-response curve was constructed and the 50% effective dose (ED50) was calculated for each study group.RESULTS:
The coinjection group of lamotrigine with morphine blocked the development of tolerance, as was shown by the preservation of morphine antinociception over 7 days and the concomitant decrease in the ED50 values on day 8, as compared with the morphine-alone group. Coinjection of lamotrigine blocked the development of morphine tolerance, as shown by the preservation of morphine antinociception over 7 days and the concomitant decrease in the ED50 values on day 8, as compared with the morphine-alone group.CONCLUSIONS:
This study suggests that lamotrigine augments the antinociceptive action of both acute and chronic morphine therapy, and it also attenuates the antinociceptive morphine tolerance in rats.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Triazines
/
Injections, Spinal
/
Water
/
Rats, Sprague-Dawley
/
Morphine
Limits:
Animals
Language:
English
Journal:
Korean Journal of Anesthesiology
Year:
2009
Type:
Article
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