Expression and significance of secretagogue in neuroendocrinal tumors / 中国医师进修杂志

ABSTRACT

Objective To explore the expression and clinical significance of secretagogne (SCGN) in neuroendocrinal tumors.Methods Immunohistochemistry was applied for detecting expression of SCGN,chromogranin A (CgA),synaptophysin (Syn) and neuronspecific enolase (NSE) in 45 cases of neuroendocrinal tumors.The difference between the expression of SCGN and the remaining indicators were compared.And different expression profiles of SCGN between groups categorized by sex,age and degree of differentiation were also compared.Results The positive expression rate of SCGN,CgA,Syn and NSE in neuroendocrinal tumors was 95.56％ (43/45),100.00％ (45/45),46.67％ (21/45) and 88.89％ (40/45) respectively,and the differences among them were statistically significant(P ＜ 0.01).Expression of SCGN was not correlated with the patient's sex,age and degree of differentiation (P＞ 0.05).Conclusions Most cases of neuroendocrinal tumors are positive for SCGN and SCGN is more sensitive than CgA.Syn is the most sensitive one for diagnosis of neuroendocrinal tumors.SCGN can be seen as a novel neuroendocrinal marker in the clinical diagnosis of neuroendocrinal tumors.