Observation of the effect of ilaprazole in treatment of peptic ulcer / 中国基层医药

ABSTRACT

Objective To observe the clinical effect of ilaprazole in the treatment of peptic ulcer.Methods 100 patients with peptic ulcer were randomly divided into omeprazole group and ilaprazole group,50 cases in each group.The patients were given omeprazole or ilaprazole combined with amoxicillin and clarithromycin.The treatment effects and clinical symptom relief satisfaction rate were compared between the two groups.Results After treatment,the results under gastroscopyin ilaprazole group,20 cases cured,16 cases healed,9 cases were effective and 5 cases were invalid.Those in omeprazole group were 14 cases,12 cases,12 cases,12 cases respectively.The differences between the two groups were statistically significant(U =3.78,P ＜ 0.05).The removal rate of Helicobacter pylori and clinical symptom relief satisfaction rate of ilaprazole group were significantly higher than those of the omeprazole group(x2 =3.84,4.57,P ＜ 0.05).Conclusion Ilaprazole can obtain good clinical effect in treatment of peptic ulcer,with high symptom relief satisfaction rate and clearance of Helicobacter pylori.