Study on differentially expressed serum proteins in Uyghur patients with primary hyperuricemia / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12): 792-794, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-442876
ABSTRACT
2-Dimensional gel electrophoresis and matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometry (MALDI-TOF-MS) were used to screen differentially expressed serum proteins in Uyghur patients with hyperuricemia and control subjects.Western blot was used to validate differential proteins.Gel-image analysis revealed that there were 11 differential protein spots.A total of 4 differential protein spots were successfully identified by MALDI-TOF-MS.Complement 3,complement 4,haptoglobin,and apolipoprotein Al levels were up-regulated in patients as compared with controls.The result of complement 3 expression was validated by Western blot,which is accordant with that of proteomics.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Endocrinology and Metabolism
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS