Pioglitazone inhibits atrial ionic channel remodeling in diabetic rabbits hearts / 中华急诊医学杂志
Chinese Journal of Emergency Medicine
;
(12): 181-186, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-443026
ABSTRACT
Objective To investigate the effects of pioglitazone on atrial ionic channel remodeling in alloxan-induced diabetic rabbit models.Methods A total of 32 rabbits were randomly (random number) divided into control (CN) group,diabetes mellitus (DM) group,diabetes mellitus + pioglitazone 4 mg/ (d · kg) (DPG) group and diabetes mellitus + double pioglitazone 8 mg/ (d · kg) (DPI) group.The diabetic state was examined by quantitative determination of blood glucose levels of ≥ 14 mmol/L.Langendorff-perfused rabbit hearts were used to isolate single atrial myocyte,and whole-cell patch-clamp technique was used to record action potential duration (APD) and atrial ionic channel currents (ICa,L and INa).Variables with normal distribution were compared with One-way ANOVA and LSD-t test.Results Compared with controls,APD90 and APDS0 of left atrial myocytes were significantly prolonged in DM group (P <0.05 vs.CN),and there was no significant difference in APD90 frequency adaptation between them (P >0.05 vs.CN).The densities of INa were reduced and the densities of ICa,L were increased in DM group (P < 0.01 vs.CN).The above variables were markedly attenuated in DPG and DPI group.Conclusions Pioglitazone may inhibits atrial ionic channel remodeling in diabetic rabbit models.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Emergency Medicine
Year:
2014
Type:
Article
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