Investigation of the correlative factors for osteoporosis among senile patients with chronic diseases / 中华老年医学杂志

ABSTRACT

Objective To investigate the correlative factors for osteoporosis among senile patients with multiple cardiovascular diseases and type 2 diabetes mellitus.Methods 206 patients were divided into osteoporosis (OP) group and non-osteoporosis (non-OP) group according to the diagnosis standards of osteoporosis.The general data were recorded.Clinical history of all kinds of cardiovascular diseases and type 2 diabetes mellitus were detected.Serum levels of hemoglobin (Hb),glucose (Glu),glucosylated hemoglobin (HbA1c),alkaline phosphatase (ALP),total serum protein (TP),albumin (ALB),BUN,creatinine (Cr),calcium (Ca),phosphonium (P),total cholesterol (TC),triglyceride (TG),high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C) were detected.Dual-energy Xray absorptiometry was used to detect the bone mineral density (BMD) of bilateral femoral neck and lumbar spine.The related factors of BMD were analyzed.Results The morbidity of osteoporosis was much higher in elderly females than in elderly males (58.7％ vs.38.6％).The osteoporosis patients were older than non-osteoporosis patients in both males and females,although there was no significant difference.The body mass index (BMI) of both gender was much lower in osteoporosis group than in non-osteoporosis group (P＜0.05).In male patients,BMD was positively correlated with BMI significantly (P＜0.01).In female patients,TC and LDL C were higher in OP group than in non-OP group (P＜0.05).In female patients,BMD was positively correlated with BMI,and negatively correlated with TC and LDL-C.Logistic regression analysis showed that the lower BMI was an independent risk factor for osteoporosis in male patients; BMI and TC were independent risk factors for osteoporosis in female patients.Conclusions In both male and female,senile patients with lower BMI,multiple cardiovascular diseases and type 2 diabetes mellitus have higher risks for osteoporosis.In senile female patients,TC may be correlated with BMD.TC should be reduced to decrease the risks of cardiovascular diseases and osteoporosisin senile females.