Polymorphism in the Promoter Region of SEMA5A Is Associated with Sociality Traits in Korean Subjects with Autism Spectrum Disorders
Psychiatry Investigation
;
: 876-878, 2017.
Article
in English
| WPRIM
| ID: wpr-44333
ABSTRACT
In this study, we evaluated the association between autism spectrum disorders (ASDs) and 10 single-nucleotide polymorphisms (SNPs) in the 5' region of the semaphorin 5A gene (SEMA5A) for 250 Korean trios including children with ASDs. Family-based association testing and haplotype analysis revealed a statistically significant association between rs194085 and multiple sociality traits with Korean ASDs in the dominant model (p < 0.001, corrected p=0.035). This indicates that genetic variations in the 5' region of SEMA5A play a role in the genetic predisposition to sociality traits in Korean ASDs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autistic Disorder
/
Genetic Variation
/
Haplotypes
/
Promoter Regions, Genetic
/
Genetic Predisposition to Disease
/
Semaphorins
/
Autism Spectrum Disorder
Limits:
Child
/
Humans
Language:
English
Journal:
Psychiatry Investigation
Year:
2017
Type:
Article
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