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Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease: Methodology and Baseline Sample Characteristics
Psychiatry Investigation ; : 851-863, 2017.
Article in English | WPRIM | ID: wpr-44336
ABSTRACT

OBJECTIVE:

The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's disease (KBASE) aimed to recruit 650 individuals, aged from 20 to 90 years, to search for new biomarkers of Alzheimer's disease (AD) and to investigate how multi-faceted lifetime experiences and bodily changes contribute to the brain changes or brain pathologies related to the AD process.

METHODS:

All participants received comprehensive clinical and neuropsychological evaluations, multi-modal brain imaging, including magnetic resonance imaging, magnetic resonance angiography, [11C]Pittsburgh compound B-positron emission tomography (PET), and [18F]fluorodeoxyglucose-PET, blood and genetic marker analyses at baseline, and a subset of participants underwent actigraph monitoring and completed a sleep diary. Participants are to be followed annually with clinical and neuropsychological assessments, and biannually with the full KBASE assessment, including neuroimaging and laboratory tests.

RESULTS:

As of March 2017, in total, 758 individuals had volunteered for this study. Among them, in total, 591 participants–291 cognitively normal (CN) old-aged individuals, 74 CN young- and middle-aged individuals, 139 individuals with mild cognitive impairment (MCI), and 87 individuals with AD dementia (ADD)–were enrolled at baseline, after excluding 162 individuals. A subset of participants (n=275) underwent actigraph monitoring.

CONCLUSION:

The KBASE cohort is a prospective, longitudinal cohort study that recruited participants with a wide age range and a wide distribution of cognitive status (CN, MCI, and ADD) and it has several strengths in its design and methodologies. Details of the recruitment, study methodology, and baseline sample characteristics are described in this paper.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Brain / Aging / Magnetic Resonance Imaging / Biomarkers / Genetic Markers / Prospective Studies / Cohort Studies / Magnetic Resonance Angiography / Dementia Type of study: Diagnostic study / Etiology study / Incidence study / Observational study / Prognostic study / Risk factors / Screening study Language: English Journal: Psychiatry Investigation Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Brain / Aging / Magnetic Resonance Imaging / Biomarkers / Genetic Markers / Prospective Studies / Cohort Studies / Magnetic Resonance Angiography / Dementia Type of study: Diagnostic study / Etiology study / Incidence study / Observational study / Prognostic study / Risk factors / Screening study Language: English Journal: Psychiatry Investigation Year: 2017 Type: Article