Effects of hemoperfusion combined with hemodialysis on micro inflammation and malnutrition status in patients with maintenance of hemodialysis patients with maintenance of hemodialysis / 中国中西医结合急救杂志

ABSTRACT

Objective To evaluate the effects of blood perfusion(HP)combined with hemodialysis(HD)on micro inflammation and malnutrition status in patients with maintenance of hemodialysis(MHD). Methods Eighty MHD patients admitted to blood purification center of Wuhan Puai Hospital in Hubei Province were enrolled and randomly divided into two groups. Pure HD group underwent conventional HD for 4 hours,3 times a week,and based on the weekly HD series,the HD+HP group took additionally HP once a week,the therapeutic course in both groups being consecutive 12 weeks. Blood was collected before and after treatment for detection of interleukin-6. (IL-6) and tumor necrosis factor-α(TNF-α) levels by enzyme-linked immunosorbent assay (ELISA), and the serum high sensitivity C-reactive protein (hs-CRP) and homocysteine (Hcy) levels were determined with electrochemiluminescence immunoassay,and the changes in nutritional indexes of hemoglobin(Hb),total protein(TP), albumin(Alb),transferrin(TRF)were observed. Results Compared with the indexes before treatment,in HD+HP group,hs-CRP(ng/L5.65±2.21 vs. 13.91±2.10),IL-6(ng/L50.10±6.65 vs. 101.22±21.32),TNF-α(ng/L80.21±9.41 vs. 197.64±25.47),Hcy(μmol/L13.31±2.21 vs. 40.96±9.42)were significantly decreased (all P0.05). There were statistical significant differences in above indexes after treatment between HD+HP group and HD group〔hs-CRP (ng/L)5.65±2.21 vs. 13.22±1.10,IL-6(ng/L)50.10±6.65 vs. 100.32±25.24,TNF-α(ng/L)80.21±9.41 vs. 196.87±24.54,Hcy(μmol/L)13.31±2.21 vs. 37.23±8.33,Hb(g/L)106.65±22.21 vs. 94.22±13.10,TP (g/L)62.10±22.65 vs. 51.32±12.32,Alb(g/L)38.21±6.41 vs. 32.87±4.54,TRF(μg/L)196.31±22.21 vs. 162.23±15.33,all P<0.05〕. Conclusion HP combined with HD in the treatment of MHD can improve the micro inflammation and malnutrition state in patients with MHD.