Fibrosis in Skeletal Muscle:Celluar and Molecular Mechanism (review) / 中国康复理论与实践
Chinese Journal of Rehabilitation Theory and Practice
;
(12): 142-147, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-443698
ABSTRACT
Skeletal muscle has high regenerative capability. It is able to regenerate completely after acute traumatic damage, while the repairing process often accompanied by fibrosis in the chronic degenerative conditions such as muscular dystrophy and repeated muscle fi-ber damage. Through in-depth study on the mechanisms of skeletal muscle fibrosis in the past decade, it has been found that a variety of cells and regulatory molecules involved in the process, especially muscle satellite cells-derived myofibroblasts, transforming growth factor β(TGF-β) and other fibrosis promoting growth factors. This review focused on the cellular and molecular mechanisms of the skeletal muscle fibrosis and relevant antagonistic strategies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Rehabilitation Theory and Practice
Year:
2014
Type:
Article
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