Effects ofα-Zearalanol on Cognitive Impairment Induced byβ-amyloid in Mice / 中国康复理论与实践

ABSTRACT

Objective To explore the effect of α-zearalanol (α-ZAL) onβ-amyloid (Aβ) induced mice and the mechanism. Methods The model was induced by intracerebroventricular injection of Aβ25-35. The mice were divided randomly into sham group, model group, estradiol benzoate (EB) group (Aβ+EB) as a positive control andα-ZAL (Aβ+α-ZAL) group. Morris water maze was used to evaluate the learning and memory ability. The levels of antioxidant enzymes and nitric oxide system in the brain tissue were detected with spectrophotometric and sotopic method. Results The escape latency was longer in the model group than in the control group (P0.05). There was no significant difference between EB group andα-ZAL group (P>0.05). Conclusionα-ZAL could improve the cognitive behavior in Aβ25-35 induced mice by increasing the antioxidant activities and de-creasing the lipid peroxidation.