Three-dimensional bioprinting technology in tissue engineering / 中国组织工程研究

ABSTRACT

BACKGROUND:Three-dimensional bioprinting technology is the emerging technology in recent years, which is one of the branches of tissue engineering. The three-dimensional bioprinting technology has been used in the reproduction process of in vitro tissues and organs, which has achieved surprising outcomes. OBJECTIVE:To review the three-dimensional bioprinting technology in terms of its principles, operating steps, relationships with tissue engineering, advantages and chal enges, as wel as clinical applications. METHODS:The first author did a computer-aided retrieval of the PubMed database, CNKI database, and CQVIP database for articles relevant to three-dimensional bioprinting technology used in tissue engineering published between January 2000 and October 2000. The key words were“three-dimensional bioprinting, tissue engineering, rapid prototyping technology, scaffold materials, selective laser sintering, fuseddeposition modeling, stereolithography”in English and Chinese. Repetitive studies were excluded, and 52 of 79 related literatures were adopted in result analysis. RESULTS AND CONCLUSION:Three-dimensional bioprinting technology is one of the branches of tissue engineering, which can build a virtual three-dimensional structure layer by layer under the computer-aided design technology, with the help of imaging data information (including CT and MRI). This technology has the advantages of high precision, high building speed, fabrication on demand, and also has the chal enges in engineering mechanics and biological activities. In a word, it is a meaningful and promising technology in clinical application.