Vertebroplasty for treatment of osteoporotic vertebral compression fractures with intravertebral cleft / 中国组织工程研究

ABSTRACT

BACKGROUND:Clinical practice verified that percutaneous vertebroplasty in the treatment of osteoporotic vertebral compression fractures obtained obvious curative effects. OBJECTIVE:To compare the therapeutic effect of percutaneous vertebroplasty for treatment for osteoporotic vertebral compression fractures with or without intravertebral cleft, in order to evaluate the efficacy and safety of percutaneous vertebroplasty for treatment of osteoporotic vertebral compression fractures. METHODS:A total of 76 patients with osteoporotic vertebral compression fractures were selected and divided into two groups. Experimental group consisted of 27 patients with intravertebral cleft. Control group comprised 49 patients without intravertebral cleft. After vertebroplasty, visual analogue scale and Oswestry disability index, changes of anterior vertebral height, and types and characteristics of bone cement leakage were compared between the two groups. RESULTS AND CONCLUSION:Visual analogue scale and Oswestry disability index were significantly decreased after treatment in the two groups (P0.05). No significant difference in the height of injured vertebra was detectable between pretreatment and posttreatment in the two groups (P>0.05). These results suggested that vertebroplasty is an effective method for lessening the pain in osteoporotic vertebral compression fractures in patients with or without intravertebral cleft, improving spinal activity function and elevating social activities. However, percutaneous vertebroplasty cannot effectively recover the height of the vertebra.