Research progress of calcification and anti-calcification of implanted silicone rubber / 国际生物医学工程杂志
International Journal of Biomedical Engineering
; (6): 57-60, 2014.
Article
in Zh
| WPRIM
| ID: wpr-444158
Responsible library:
WPRO
ABSTRACT
Calcification of silicone rubber is a pathologic mineralization phenomenon which occurs on the surface after it is implanted in vivo,and there is no effective prevention method.The important process of calcification including these steps:phosphate ions combined with calcium ions to promote nucleating aggregation,slow increasing,fusion,and gradually form a larger accumulation of hydroxyapatite calcium.The research had been developed to the level of cells and genes,such as matrix Gla protein clusters is a calcification inhibitor of the tissues around silastic prosthesis.It is necessary to obtain a theoretical breakthrough in the aspect of organic template modulation of inorganic crystals.Silicone elastomer having its own local anti-calcification property had been paid more attention.Fully revealing the mechanism of calcification and calcification-resistant of silicone rubber will probably provide the basis for building a new anti-calcification material.
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WPRIM
Language:
Zh
Journal:
International Journal of Biomedical Engineering
Year:
2014
Type:
Article