Clinical significance of the serum transforming growth facto-1,interleukin-10,interferon-γ in of patients with hepatic fibrosis / 中国综合临床
Clinical Medicine of China
;
(12): 41-43, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-444261
ABSTRACT
Objective To investigate the changes of serum transforming growth factor-β1 (TGF-β1),interleukin-10(IL-10) and interferon-γ(INF-γ) in elderly patients with hepatic fibrosis and their correlation with hepatic fibrosis.Methods One hundred and thirty-three patients diagnosed by pathological hepatic tissue were enrolled as case group who were in the first affiliated hospital of Xinxiang Medical University from 2007 to 2013.The enzyme-linked immunosorbent assay (ELISA) was applied to detect of serum levels of TGF-β1,IL-10and IFN-γ.Meanwhile 21 healthy people were recruited as control group.Results Comparison with the control group,the levels of TGF-β1 and IL-10 were significantly higher(TGF-β1(217.4 ± 7.5) ng/L vs.(57.2±4.8) ng/L,t =15.61,P<0.01;IL-10(29.6 ±3.2) ng/L vs.(15.1 ±7.5) ng/L,t =11.44,P<0.01),while IFN-γlevel was lower ((51.9 ± 3.5) ng/L vs.(75.8 ± 5.9) ng/L,P =0.03) in case group.The serum levels of TGF-β1,IL-10,IFN-γand stages of hepatic fibrosis was correlated and the correlation coefficients were 0.786,0.644 and-0.822 respectively (P < 0.05).Conclusion Serum levels of TGF-β1,IL-10 and IFN-γ in patients with hepatic fibrosis are proved to be with ability of predicting the development of hepatic fibrosis and the post treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Clinical Medicine of China
Year:
2014
Type:
Article
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