Research on the factors related to heterogeneity of response to montelukast in children with asthma / 国际儿科学杂志

ABSTRACT

As the application of leukotriene receptor antagonists (LTRA) is widely used among children with asthma,the heterogeneity of response to montelukast and its related factors are attracting more and more attention.At present,the research has made some progresses,but it is still in the stage of development and cannot reach a consensus.The related factors,including individual characteristics,body mass index,smoking exposure,genetic factors are described in this review,to improve the rationality of drug selection in order to reduce side effects 、improving therapeutic efficacy and achieve good asthma control.