Relationship between levels of serum IgA1 and underglycosylated IgA1 and renal function in children with allergic purpura / 中国医师进修杂志

ABSTRACT

Objective To discuss the relationship between levels of serum IgA 1 and underglycosylated IgAl and renal function in children with allergic purpura.Methods Fifty-nine children with allergic purpura including 32 cases of renal damage group and 27 cases of non-renal damage group and 12 healthy children as control group were chosen.Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of serum IgA1 and underglycosylated IgA1[the binding capacity of vilsa villosa lectin(VVL) to serum IgA1],children in renal damage group were separated into 3 groups＜ 0.5 MOM,0.5-1.5 MOM and ＞ 1.5 MOM according to the multiples of the median(MOM) of the level of serum IgA 1 and underglycosylated IgA 1.Serum creatinine (SCr),blood urea nitrogen (BUN) and serum uric acid (SUA) were tested by completely automatic biochemistry analyzer.Results The levels of serum IgA1 and underglycosylated IgA1 in control group [(1.07 ±0.68) g/L,(1.26 ±0.92) AU/mg] were significantly lower than that in renal damage group [(2.26 ± 0.77) g/L,(3.78 ± 0.64) AU/mg] and non-renal damage group [(1.75 ± 0.53) g/L,(2.02 ± 0.76) AU/mg],and there were differences among these groups (P ＜ 0.05).According to MOM of the level of serum IgA1＜0.5 MOM group(6 cases),0.5-1.5 MOM group(17 cases) and ＞ 1.5 MOM group(9 cases),there was significant difference in the level of serum IgA1 among three groups (P ＜0.01),but there was no significant difference of SCr,BUN and SUA among three groups (P ＞ 0.05).According to MOM of the level of serum underglycoeylated IgA1＜0.5 MOM group (8 cases),0.5-1.5MOM group (13 cases) and ＞ 1.5 MOM group (11 cases),there was significant difference in the level of serum underglycosylated IgA1,SCr,BUN among three groups (P ＜ 0.01),but there was no significant difference of SUA among three groups (P ＞ 0.05).Correlation analysis showed that the level of serum IgA1 was no correlation with SCr,BUN,SUA (r =2.88,1.44,1.66,P ＞ 0.05);the level of serum underglycosylated IgA1 was positive correlation with SCr,BUN(r =1.12,1.99,P＜ 0.05),but no correlation with SUA(r =2.88,P＞ 0.05).Conclusions The level of serum IgA1 can't reflect the degree of impairment of kidney damage,underglycosylated IgA1 level is significantly positively correlated with the renal function.There are more severe degree of renal function damage in the higher underglycosylated IgA1 level in children with allergic purpura.