Effect of torasemide or furosemide combined with mannitol in treatment of acute cerebral hemorrhage patients with cerebral edema / 中国医师进修杂志

ABSTRACT

Objective To compare the effect of torasemide or furosemide combined with mannitol in the treatment of acute cerebral hemorrhage patients with cerebral edema.Methods One hundred and sixty patients with cerebral hemorrhage were selected,and divided into torasemide group and furosemide group according to different treatment methods,40 cases in each.The torasemide group was treated with torasemide combined with 20％ mannitol,the furosemide group was treated with furosemide combined with 20％ mannitol.The curative effect,mannitol dosage,edema volume,24 h urine and adverse reactions in two groups were compared.Results The total effective in torasemide group was higher than that in furosemide group [97.5％ (78/80) vs.77.5％ (62/80)],mannitol dosage was less than that in furesemide group [(347.5 ±32.5) ml vs.(438.2 ±30.7) ml],the incidence of adverse reactions was lower than that in furosemide group [7.5％(6/80) vs.27.5％(22/80)],which reached statistical significance (P＜ 0.01 or ＜ 0.05).The edema volume in the 7th,14th day in torasemide group was less than those in furosemide group [(21.1 ±3.4) ml vs.(23.3 ±4.8) ml,(17.6 ±4.5) ml vs.(22.4 ±5.6) ml],the 24 h urine in the 3re,7th,14th day were more than those in furosemide group [(3 684 ±528) ml vs.(3 429 ±592) ml,(3 854 ± 746) ml vs.(3 185 ±490) ml,(3 742 ±t658) ml vs.(2 251 ± 324) ml],which reached statistical significance (P ＜ 0.05).Conclusions Torasemide in treatment of acute cerebral hemorrhage patients has better efficacy and safety.It is better than furosemide.