Clinical observation of Tripterygium wilfordii tablets in the treatment of intractable psoriasis / 中国基层医药

ABSTRACT

Objective To investigate the clinical efficacy of Tripterygium wilfordii tablets in the treatment of intractable psoriasis.Methods 66 patients with intractable psoriasis according to the time of admission were randomly divided into two groups.The treatment group was treated with Tripterygium wilfordii tablets,the control group was given erythromycin combined with Glycyrrhizin.During treatment period,the blood and urine were checked every two weeks,the liver and kidney function were examined monthly.After treatment for 6 weeks,the clinical efficacy and side effects were observed in two groups.The patients were followed up for 2 years,the recurrence was observed.Results In the treatment group,8 cases were cured,effective in 15 cases,8 cases were improved,2 cases were ineffective,the total effective rate was 69.7％.Those in the control group were 2 cases,7 cases,5 cases,19 cases,the total effective rate was 27.3％,the difference between the two groups was statistically significant (x2 =7.34,P ＜ 0.05).In the treatment group,mild dizziness in 1 case,transaminase increased in 1 case,irregular menstruation in 1 case,accounted for 9.1％.In the control group,3 cases occured mild dizziness,1 case occured anorexia,transaminase increased in 1 case,irregular menstruation in 1 case,accounted for 18.2％.2 weeks after withdrawal of the drug,they all returned to normal.The incidence rate of side effects between the two groups had statistically significant difference (x2 =3.37,P ＜ 0.05).In the treatment group,1 case relapsed within 1 year,2 cases relapsed within 2 years,the total recurrence rate was 9.1％.In the control group,5 cases relapsed within 1 year,7 cases relapsed within 2 years,the recurrence rate was 39.4％,there was significant difference between the two groups (x2 =5.79,P ＜ 0.05).Conclusion Tripterygium wilfordii tablets in the treatment of refractory psoriasis has short response time,good clinical effect,less side effects,and good long-term effect,which is worthy of promotion.