Effects of Chinese Medicine Compound ZDS on Serum SOD and MDA of Burn Rats / 昆明医科大学学报

ABSTRACT

Objective To investigate the protective effects of Chinese medicine compound ZDS against digestive tact damage caused by oxygen free radical after the burns. Methods 20 SD rats were randomly divided into ZDS (with ZDS treatment,n=10) and Con (control,n=10) groups. The rats were inflicted with 30%TBSA full thickness burn on the back and fed with Chinese medicine compound ZDS or warm water (2 mL/time,2 times a day) . On the 3rd and 9th postburn day, the serum samples were harvested from portal vein and the serum superoxide dismutase (SOD) activity,the levels of malondiadehycle (MDA) were detected. Meanwhile, the bacteria translocation of parenteral organs and the histology of intestine were also observed. Results The SOD activity in ZDS group on day 9 post burn increased significantly than that in Con group( <0.05);but at the same timepoint, compared with Con group, the MDA level in ZDS group was decreased obviously ( <0.05) . Conclusion Chinese medicine compound ZDS can partly protect the digestive tact against damage caused by oxygen free radical after the burns.