Design, synthesis, and PPARgamma agonistic activity of novel indenone derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 508-13, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-445610
ABSTRACT
Agonists of peroxisome proliferator-activated receptor gamma (PPARgamma) are of interest as a treatment of type II diabetes, and indenone derivatives are a new class of non-TZD PPARgamma agonists. Based on existing indenone derivatives, a series of novel ones have been designed and synthesized. Meanwhile the structures have been comfirmed with 1H NMR and MS. Among them, 17b and 19 showed higher agonistic activities than rosiglitazone.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS